Charles D Burger Selected Research

lenzilumab

1/2022	Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial.
5/2021	LENZILUMAB EFFICACY AND SAFETY IN NEWLY HOSPITALIZED COVID-19 SUBJECTS: RESULTS FROM THE LIVE-AIR PHASE 3 RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL.
11/2020	GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort Study.
6/2020	First Clinical Use of Lenzilumab to Neutralize GM-CSF in Patients with Severe COVID-19 Pneumonia.

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Charles D Burger Research Topics

Disease

16	Pulmonary Arterial Hypertension 01/2023 - 09/2014
13	Pulmonary Hypertension 01/2024 - 09/2007
8	COVID-19 01/2022 - 01/2020
6	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 07/2019 - 11/2005
5	Hypertension (High Blood Pressure) 12/2022 - 06/2009
5	Pneumonia (Pneumonitis) 01/2022 - 10/2005
4	Lung Diseases (Lung Disease) 01/2022 - 10/2015
3	Heart Failure 01/2022 - 11/2014
2	End Stage Liver Disease 12/2022 - 01/2022
2	Cytokine Release Syndrome 05/2021 - 06/2020
2	Inflammation (Inflammations) 05/2021 - 01/2018
2	Familial Primary Pulmonary Hypertension 01/2021 - 06/2009
2	Respiratory Insufficiency (Respiratory Failure) 06/2020 - 02/2003
2	Edema (Dropsy) 01/2020 - 07/2003
2	Vascular Diseases (Vascular Disease) 09/2019 - 01/2018
2	Neoplasms (Cancer) 07/2019 - 01/2018
2	Infections 01/2018 - 03/2004
2	Chronic Obstructive Pulmonary Disease (COPD) 03/2017 - 04/2009
1	Chronic Renal Insufficiency 01/2024
1	Interstitial Lung Diseases (Interstitial Lung Disease) 04/2022
1	Congenital Heart Defects (Congenital Heart Defect) 01/2022
1	Diabetes Mellitus 01/2022
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2021
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2020
1	Systemic Scleroderma (Systemic Sclerosis) 09/2019
1	Rare Diseases (Rare Disease) 07/2019
1	Lymphangiomyoma 07/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2018
1	Disease Progression 01/2018
1	Cysts 10/2015
1	Ureteral Obstruction 10/2015
1	Chylothorax 10/2015
1	Myalgia 11/2014

Drug/Important Bio-Agent (IBA)

4	lenzilumabIBA 01/2022 - 06/2020
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2022 - 06/2020
4	Oxygen (Dioxygen)IBA 05/2021 - 04/2009
4	lipoarabinomannan (LAM)IBA 07/2019 - 10/2015
4	Sirolimus (Rapamycin)FDA Link 07/2019 - 01/2011
3	treprostinil FDA Link 01/2023 - 03/2017
2	SodiumIBA 12/2022 - 07/2015
2	Phosphodiesterase 5 InhibitorsIBA 04/2022 - 11/2014
2	Monoclonal AntibodiesIBA 01/2022 - 06/2020
2	fibrin fragment D (D-dimer)IBA 05/2021 - 06/2009
2	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 09/2019 - 09/2014
2	Prostaglandins IIBA 03/2018 - 01/2016
2	Epoprostenol (Prostacyclin)FDA LinkGeneric 03/2018 - 09/2014
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2024
1	Iloprost (Ventavis)FDA Link 01/2023
1	BilirubinIBA 12/2022
1	PowdersIBA 04/2022
1	Endothelin Receptor AntagonistsIBA 04/2022
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 04/2022
1	riociguatIBA 04/2022
1	Immunologic Factors (Immunomodulators)IBA 01/2022
1	VaccinesIBA 01/2022
1	SteroidsIBA 01/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2021
1	ChemokinesIBA 05/2021
1	CytokinesIBA 05/2021
1	remdesivirIBA 05/2021
1	Ferritins (Ferritin)IBA 05/2021
1	Angiotensin Receptor AntagonistsIBA 01/2021
1	7-(N-(3-aminopropyl)amino)heptan-2-oneIBA 01/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2021
1	Antihypertensive Agents (Antihypertensives)IBA 01/2021
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	Investigational DrugsIBA 11/2020
1	ambrisentan FDA Link 01/2020
1	Nifedipine (Adalat)FDA LinkGeneric 09/2019
1	HLA-DPB1 antigen (HLA DPB1)IBA 01/2019
1	HLA-DPA1 antigen (HLA DPA1)IBA 01/2019
1	Brain Natriuretic Peptide (Natrecor)FDA Link 05/2018
1	Biomarkers (Surrogate Marker)IBA 05/2018
1	AutoantibodiesIBA 01/2018
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2018
1	Anesthetics (Anesthetic Agents)IBA 01/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2018
1	macitentanIBA 07/2017
1	Estrogens (Estrogen)FDA Link 06/2017
1	Aromatase InhibitorsIBA 06/2017
1	Tadalafil (Cialis)FDA Link 11/2014
1	Sildenafil Citrate (Viagra)FDA Link 11/2014

Therapy/Procedure

16	Therapeutics 04/2022 - 09/2014
4	Liver Transplantation 12/2022 - 07/2003
3	Artificial Respiration (Mechanical Ventilation) 01/2022 - 07/2003
2	Mechanical Ventilators (Ventilator) 05/2021 - 06/2006
2	Aftercare (After-Treatment) 07/2019 - 08/2018
2	Transplantation 10/2005 - 03/2004
1	Contraindications 12/2022
1	Home Nursing (Nursing, Home) 01/2022
1	Intravenous Infusions 05/2021
1	Investigational Therapies (Experimental Therapy) 12/2020
1	Resuscitation 01/2020
1	Durable Medical Equipment (Medical Equipment, Durable) 01/2016
1	Pleurodesis 10/2015
1	Lung Transplantation 10/2015
1	Central Venous Catheters 11/2014